Li, Zhong-Yuan; Lakmal, Hetti Handi Chaminda; Qian, Xiaolin; Zhu, Zhenyu; Donnadieu, Bruno; McClain, Sarah J.; Xu, Xue; Cui, Xin published the artcile< Ruthenium-Catalyzed Enantioselective C-H Functionalization: A Practical Access to Optically Active Indoline Derivatives>, Application In Synthesis of 188813-04-9, the main research area is hydroindolecarboxaldehyde regioselective enantioselective preparation; ruthenium catalyst enantioselective cyclization alkenylaminobenzaldehyde transient imine directing group; study mechanism ruthenium catalyzed directed enantioselective cyclization alkenylaminobenzaldehyde.
In the presence of [Ru(p-cymene)Cl2]2, nonracemic 1-(1-naphthyl)ethylamine as a transient directing group, and N-phthaloyl-L-tert-leucine, 3-(alkenylamino)benzaldehydes such as I underwent enantioselective cyclization mediated by AgBF4 and KH2PO4 in chlorobenzene/hexafluoroisopropanol to yield nonracemic dihydroindolecarboxaldehydes such as II in up to 92% yield with 96% ee. A benzindolecarboxaldehyde potentially useful for the synthesis of lysergic acid analogs was prepared using this method. The reaction mechanism was studied using the preparation of ruthenacycles related to potential reaction intermediates, mass spectrometric detection of reaction intermediates, and deuterium labeling experiments
Journal of the American Chemical Society published new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (m-alkenylamino). 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Application In Synthesis of 188813-04-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary