Li, Ya-Wei; Zheng, Hong-Xing; Yang, Bo; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< tBuOK-Promoted Cyclization of Imines with Aryl Halides>, COA of Formula: C7H4Br2O2, the main research area is imine aryl halide aminyl radical potassium tert butoxide cyclization; indole preparation.
A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramol. coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.
Organic Letters published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, COA of Formula: C7H4Br2O2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary