In 2022,Lenis-Rojas, Oscar A.; Carvalho, Beatriz; Cabral, Rui; Silva, Margarida; Friaes, Sofia; Roma-Rodrigues, Catarina; Meireles, Marta S. H.; Gomes, Clara S. B.; Fernandez, Jhonathan A. A.; Vila, Sabela F.; Rubiolo, Juan A.; Sanchez, Laura; Baptista, Pedro V.; Fernandes, Alexandra R.; Royo, Beatriz published an article in JBIC, Journal of Biological Inorganic Chemistry. The title of the article was 《Manganese(I) tricarbonyl complexes as potential anticancer agents》.COA of Formula: C5BrMnO5 The author mentioned the following in the article:
The antiproliferative activity of [Mn(CO)3(NN)Br] (NN = phendione 1, bipy 3) and of the two newly synthesized Mn complexes [Mn(CO)3(acridine)(phendione)]OTf (2) and [Mn(CO)3(di-triazole)Br] (4) has been evaluated by MTS against three tumor cell lines A2780 (ovarian carcinoma), HCT116 (colorectal carcinoma), HCT116doxR (colorectal carcinoma resistant to doxorubicin), and in human dermal fibroblasts. The antiproliferative assay showed a dose-dependent effect higher in complex 1 and 2 with a selectivity toward ovarian carcinoma cell line 21 times higher than in human fibroblasts. Exposure of A2780 cells to IC50 concentrations of complex 1 and 2 led to an increase of reactive oxygen species that led to the activation of cell death mechanisms, namely via intrinsic apoptosis for 2 and autophagy and extrinsic apoptosis for 1. Both complexes do not target DNA or interfere with cell cycle progression but are able to potentiate cell migration and neovascularization (for 2) an indicative that their application might be directed for initial tumor stages to avoid tumor invasion and metastization and opening a new avenue for complex 2 application in regenerative medicine. Interestingly, both complexes do not show toxicity in both in vivo models (CAM and zebrafish). In addition to this study using Bromopentacarbonylmanganese(I), there are many other studies that have used Bromopentacarbonylmanganese(I)(cas: 14516-54-2COA of Formula: C5BrMnO5) was used in this study.
Bromopentacarbonylmanganese(I)(cas: 14516-54-2) has many other uses. It is used in the formation of (eta6-arene)tricarbonylmanganese(I) by reacting with arene (arene= hexamethyl benzene, 1,2,4,5-tetramethyl benzene, mesitylene, p-xylene and toluene) in the presence silver salt.COA of Formula: C5BrMnO5
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary