Klett, Johannes; Wozniak, Lukasz; Cramer, Nicolai published the artcile< 1,3,2-Diazaphospholene-Catalyzed Reductive Cyclizations of Organohalides>, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol, the main research area is dihydrobenzofurane pyrrolidine preparation photochem; aryl alkyl halide reductive cyclization diazaphospholene hydride catalyst; Cyclizations; Diazaphospholenes; Homogeneous Catalysis; Photocatalysis; Radical Reactions.
1,3,2-Diazaphospholene hydrides (DAP-Hs) are highly nucleophilic organic hydrides serving as main-group catalysts for a range of attractive transformations. DAP hydrides can act as stoichiometric hydrogen atom transfer agents in radical reactions. Herein, authors report a DAP-catalyzed reductive radical cyclization of a broad range of aryl and alkyl halides under mild conditions. The pivotal DAP catalyst turnover was achieved by a DBU-assisted σ-bond metathesis between the formed DAP halide and HBpin, which rapidly regenerates DAP-H. The transformation is significantly accelerated by irradiation with visible light. Mechanistic investigations indicate that visible light irradiation leads to the formation of DAP dimers, which are in equilibrium with DAP radicals and accelerate the cyclization. The direct use of (DAP)2 enabled a catalytic protocol in the absence of light.
Angewandte Chemie, International Edition published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Recommanded Product: 2-Bromo-4-(trifluoromethyl)phenol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary