Jiang, Jianfeng; Wang, Xia; Liu, Shengping; Zhang, Sichen; Yang, Binmiao; Zhao, Yu; Lu, Shenci published the artcile< Enantioselective Cascade Annulation of α-Amino-ynones and Enals Enabled by Gold and Oxidative NHC Relay Catalysis>, Computed Properties of 3893-18-3, the main research area is pyrrole fused lactone preparation enantioselective; amino ynone enal oxidative tandem cyclization gold catalyst; Cascade Annulation; Cycloaddition; Enantioselectivity; Gold Catalysis; Relay Catalysis.
Unprecedented gold and oxidative NHC relay catalysis enables highly enantioselective cascade annulation between readily available α-amino-ynones R1CCC(O)CH2NHR2 (R1 = H, Ph, 4-fluorophenyl, 3,5-dimethoxyphenyl, etc.; R2 = Boc, Ts, Cbz) with enals R3CH=CHC(O)H (R3 = prop-1-en-1-yl, Ph, 2-thienyl, 2-naphthyl, etc.). This method utilizes the in situ-generated pyrrolin-4-ones as a novel and versatile synthon, which engage with α,β;-unsaturated acylazolium intermediates generated from enals by oxidative NHC catalysis to produce pyrrole-fused lactones I in high yield and excellent enantioselectivity. Synthetic utility of the lactone products is also demonstrated by facile conversion to densely functionalized pyrroles/pyrrolin-4-ones e.g., II in high yields with excellent stereopurity.
Angewandte Chemie, International Edition published new progress about Alkynyl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Computed Properties of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary