Jagot, Fatema; Ntsimango, Songeziwe; Ngwira, Kennedy J.; Fernandes, Manuel A.; de Koning, Charles B. published the artcile< Synthesis of Angucycline/Tetrangulol Derivatives Using Suzuki-Miyaura Cross-Coupling and Ring-Closing Carbonyl-Olefin Metathesis Reactions>, Electric Literature of 1530-33-2, the main research area is angucycline tetrangulol preparation.
Key steps in the synthesis of derivatives of the angucycline, tetrangulol include the use of a palladium catalyzed Suzuki-Miyaura cross-coupling reaction for the assembly of I from 2-iodo-3-methoxy-5-methylbenzaldehyde and II. The biaryl product I was then subjected to an iron-catalyzed ring-closing carbonyl-olefin metathesis reaction to afford 1,7,12-trimethoxy-3-methyltetraphene, which was oxidized to the corresponding quinone III. Late stage oxidation of the quinone III with Ru[Cl2(p-cymene)]2 and an oxidant unexpectedly afforded the chlorinated compounds IV (R = H, OH).
European Journal of Organic Chemistry published new progress about Anthracyclines Role: SPN (Synthetic Preparation), PREP (Preparation). 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, Electric Literature of 1530-33-2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary