Ibrahem, Ismail; Breistein, Palle; Cordova, Armando published the artcile< One-Pot Three-Component Catalytic Enantioselective Synthesis of Homoallylboronates>, Application of C9H7BrO, the main research area is copper catalyzed asym reaction diboron unsaturated aldehyde triphenylphosphoranylidene ester; enantioselective synthesis homo allyl boronate.
Authors have developed an efficient, novel one-pot three-component enantioselective reaction between a diboron reagent, α,β-unsaturated aldehydes, and 2-(triphenylphosphoranylidene)acetate esters. The asym. multicomponent reaction proceeds through a β-boration/Wittig sequence to give the corresponding homoallylboronates with high enantiomeric ratios using simple bench-stable chiral amines and copper catalysts. In addition, the study shows that it is possible to merge the catalytic cycles of transition-metal-catalyzed nucleophilic activation of diboron reagents with amine-catalyzed iminium activation of enals to achieve a highly 1,4- and enantioselective β boration of enals. The one-pot expansion of the cocatalytic three-component reaction to the asym. synthesis of homoallylic alcs. was also disclosed. Further development of this type of one-pot multicomponent cocatalytic asym. reaction and its application in total synthesis is ongoing in authors laboratories Thus, three-component trimethylsilyl substituted pyrrolidine amine/PPh3/Cu(OTf)2-catalyzed reaction of cinnamaldehyde with B2pin2 and Ph3P:CHCO2Et in MeOH/Et2O followed by treatment with 2-fluorobenzoic acid gave 65% (S,E)-Et 5-phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pent-2-enolate stereoselectively.
Angewandte Chemie, International Edition published new progress about Amines, chiral Role: CAT (Catalyst Use), USES (Uses). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Application of C9H7BrO.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary