Huang, Wanqiao; Zhang, Ruzhong; Zhang, Ruxue; Yu, Jianxin; Wang, Mang published the artcile< Radical hydrotrifluoromethylation of ynamides: a route toward β-CF3 enamides>, Synthetic Route of 3959-07-7, the main research area is aryl trifluoromethyl amine preparation; trifluoromethyl enamide preparation diastereoselective deprotection reduction reaction; ynamide chlorophenyl trifluoromethyliodane radical hydrotrifluoromethylation reaction.
Radical hydrotrifluoromethylation of ynamides RNR2CCR1 (R = Ph, 3-chlorophenyl, benzodioxol-5-yl, etc.; R1 = H, cyclopropyl, Ph, etc.; R2 = Boc, Ac, Cbz) to provide an alternative route toward (E)-β-CF3 enamides RNR2CH=C(CF3)R1 was reported. By using PhICF3Cl as the CF3 reagent and DMF as the H-donor, the reaction occurred smoothly in the presence of NaH at room temperature Further reduction of the resulting β-CF3 enamides efficiently delivered β-CF3 amines RNHCH2CH(CF3)R1. Gram-scale synthesis was conducted to demonstrate the practicability of the method.
Organic Chemistry Frontiers published new progress about Diastereoselective synthesis. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Synthetic Route of 3959-07-7.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary