Hess, Andreas; Alandini, Nurtalya; Guelen, Hasret C.; Prohaska, Jan P.; Knochel, Paul published an article in 2022. The article was titled 《Regioselective magnesiations of functionalized arenes and heteroarenes using TMP2Mg in hydrocarbons》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Electric Literature of C7H5BrO2 The information in the text is summarized as follows:
The preparation of a new hydrocarbon-soluble magnesium amide TMP2Mg (TMP = 2,2,6,6-tetramethylpiperidyl) was report . This base showed excellent properties for the regioselective magnesiation of various arenes and heteroarenes bearing Et esters and carbamates under very mild reaction conditions. Subsequent trapping with aryl iodides (Negishi cross-coupling) gave access to a range of highly functionalized valuable building blocks such as I [R = 2-F,6-C(O)OEt, 2-F,6-C(O)Ot-Bu, 2-C(O)OEt, etc. R1 = I, 2-thienyl, 3-MeOC6H4, etc.]. The results came from multiple reactions, including the reaction of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4Electric Literature of C7H5BrO2)
Furthermore, the coupling of 5-Bromobenzo[d][1,3]dioxole(cas: 2635-13-4) with β-methallyl alcohol was catalyzed by Pd(OAc)2 in combination with P(t-Bu)3.Electric Literature of C7H5BrO2
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary