Safety of 2,5-DibromothiopheneIn 2022 ,《Water-soluble thienoviologen derivatives for imaging bacteria and antimicrobial photodynamic therapy》 was published in Journal of Materials Chemistry B: Materials for Biology and Medicine. The article was written by Guo, Mengying; Zhou, Kun; Ding, Rui; Zhao, Xiaodan; Zhang, Yueyan; Zhang, Zixi; He, Gang. The article contains the following contents:
A series of water-soluble cationic thienoviologen derivative photosensitizers (nTPy-Rs) for photodynamic therapy (PDT) is reported. Cationic pyridine groups were introduced into the thiophene framework to enhance solubility and bacteria-binding ability, which effectively improved bacteriol. imaging and antibacterial activity. The optoelectronic properties of nTPy-Rs were regulated by adjusting the number of thiophene groups, and the differences in antibacterial activity due to the functional scaffolds were compared. The results showed that nTPy-Rs could generate reactive oxygen species (ROS, including macroscopic free radicals), efficiently inhibit bacterial growth, and achieve the min. inhibitory concentration (MIC) to the ng mL-1 level. Remarkably, 2TPyC6, containing two thiophene groups and modified by alkyl side chains, showed the best bacteriostatic performance, with the MIC of 20 ng mL-1 and 4.5 ng mL-1 for E. coli and S. aureus, resp., which are the lowest photosensitizer concentrations used in PDT to date. The low cell cytotoxicity and excellent antibacterial performance give nTPy-Rs great potential as PDT agents in vivo. The experimental process involved the reaction of 2,5-Dibromothiophene(cas: 3141-27-3Safety of 2,5-Dibromothiophene)
2,5-Dibromothiophene(cas: 3141-27-3) , is mainly used as pharmaceutical intermediate and synthesis intermediate. 2,5-Dibromothiophene polymerizes by debromination with magnesium catalyzed by nickel compounds to form poly(2,5- thienylene) .Safety of 2,5-Dibromothiophene
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary