《Glucuronidation of Methylated Quercetin Derivatives: Chemical and Biochemical Approaches》 was written by Docampo-Palacios, Maite L.; Alvarez-Hernandez, Anislay; Adiji, Olubu; Gamiotea-Turro, Daylin; Valerino-Diaz, Alexander B.; Viegas, Luis P.; Ndukwe, Ikenna E.; de Fatima, Angelo; Heiss, Christian; Azadi, Parastoo; Pasinetti, Giulio M.; Dixon, Richard A.. Category: bromides-buliding-blocks And the article was included in Journal of Agricultural and Food Chemistry in 2020. The article conveys some information:
Botanical supplements derived from grapes are functional in animal model systems for the amelioration of neurol. conditions, including cognitive impairment. Rats fed with grape extracts accumulate 3′-O-methyl-quercetin-3-O-β-D-glucuronide in their brains, as a potential therapeutic agent. To develop methods for the synthesis of 3′-O-methyl-quercetin-3-O-β-D-glucuronide and the related 4′-O-methyl-quercetin-7-O-β-D-glucuronide, 3-O-methyl-quercetin-3′-O-β-D-glucuronide, and 4′-O-methyl-quercetin-3′-O-β-D-glucuronide, which are not found in the brain, we have evaluated both enzymic semi-synthesis and full chem. synthetic approaches. Biocatalysis by mammalian UDP-glucuronosyltransferases generated multiple glucuronidated products from 4′-O-methylquercetin, and is not cost-effective. Chem. synthetic methods, on the other hand, provided good results; methyl-quercetin-3-O-β-D-glucuronides were obtained in six steps at 12-30% overall yield, resp., while 4 was synthesized in five steps at 34% overall yield. A mechanistic study on the unexpected regioselectivity observed in the quercetin glucuronide synthetic steps is also presented. The results came from multiple reactions, including the reaction of (2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Category: bromides-buliding-blocks)
(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Category: bromides-buliding-blocks
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary