Chidananda, N.; Poojary, Boja; Sumangala, V.; Kumari, N. Suchetha; Shetty, Prashanth; Arulmoli, T. published the artcile< Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles>, Category: bromides-buliding-blocks, the main research area is disubstituted triazolothiadiazole dihydrodisubstituted triazolothiadiazole synthesis antiinflammatory analgesic antioxidant antimicrobial; amino bromo methoxyphenyl dihydro triazolethione cyclocondensation carboxylic acid aldehyde; bromomethoxy benzoic acid cyclization hydrazone Mannich reaction condensation.
Two new series of compounds namely, 3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (I) (R1 = 4-methoxy Ph, 4-Me Ph, Ph, 3,5-dichlorophenyl, 4-aminophenyl, 3,5 -dimethyl Ph, 4-nitro Ph, 3,5 -dinitro Ph, 2-hydroxy-4-Me Ph, 2,4 -diiodo phenyl) and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (II) (R1 = 2-chloro Ph, Ph, 4-chloro Ph, 3-chlorophenyl, 2,4-dimethoxy Ph, 4-methoxy Ph, 2-methoxy Ph, 4-nitro Ph, biphenyl, 4-Me phenyl) were prepared In continuation of a previously reported study, the first series I were synthesized by the cyclocondensation of 4-amino-5-(2-bromo-5-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (III) with various substituted aromatic carboxylic acids in phosphorus oxychloride and the second series I by the reaction of III with various substituted aromatic aldehydes in the presence of p-Toluene sulfonic acid. Reaction of III with the aldehyde (IV) afforded the Schiff’s base (V) and not the cyclized product on treatment with p-Toluene sulfonic acid. Synthesized compounds were structurally confirmed by spectral anal. and studied for their anti-inflammatory, analgesic, anti-oxidant and antimicrobial activities. Some of the tested compounds showed significant pharmacol. activities.
European Journal of Medicinal Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary