Chacon-Huete, Franklin; Covone, Jason; Zaroubi, Liana; Forgione, Pat published the artcile< Efficient Synthesis of Bis(5-arylfuran-2-yl)methane Scaffolds Utilizing Biomass-Derived Starting Materials>, SDS of cas: 401-78-5, the main research area is bisfuryl methane preparation green chem; aryl hydroxy methyl furan condensation; bromide aryl hydroxymethylfuroic acid decarboxylative cross coupling.
A new synthetic route utilizing biomass-derived furans like 5-hydroxymethylfuroic acid as a starting material for the production of bis(5-arylfuran-2-yl)methane scaffolds I (R = 4-F, 2-Me, 4-OMe, etc.) was developed. Decarboxylative cross-coupling of 5-hydroxymethylfuroic acid (HMFA) was studied in detail with overall good yields. Acid-catalyzed self-condensation was optimized to produce the target structures I in excellent yields. Overall, this report introduces a new expedient synthesis to obtain bis(furyl) methane scaffolds I that avoids the use of protecting groups and highlights the utilization of renewable carbon sources as starting materials.
European Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, SDS of cas: 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary