Carullo, Gabriele; Mazzotta, Sarah; Giordano, Francesca; Aiello, Francesca published the artcile< Green synthesis of new pyrrolo [1,2-a] quinoxalines as antiproliferative agents in GPER-expressing breast cancer cells>, Computed Properties of 51605-97-1, the main research area is pyrroloquinoxaline GPER breast cancer antiproliferative activity.
4,5-Dihydropyrrolo [1,2-a]quinoxalines are interesting druggable scaffolds, with multifaceted biol. properties, including anticancer properties targeting the G protein-coupled estrogen receptor 1 (GPER). In this work, the synthesis and preliminary antiproliferative activity of a small set of new 4,5-dihydropyrrolo[1,2-a]quinoxalines (18-20) and pyrrolo[1,2-a]quinoxalines (21, 22) has been reported, inspired by known antiproliferative agents (G-1, G-15, and G-36). The synthesis of the pyrroloquinoxalinic core was employed following the Pictet-Spengler reaction, using the surfactant p-dodecylbenzene sulfonic acid (p-DBSA), as catalyst. It demonstrated efficiency in the catalysis of the 4-phenylpyrrole [1,2-a] quinoxaline type compound formation in mild solvents such as water, ethanol, and hydroalcoholic solutions In addition, the reactions proceeded in a short time (between 15 and 120 min) at room temperature and with high yields. The in vitro MTT assays showed that the presence of iso-Pr groups furnished promising antiproliferative compounds Although, the acetyl group provided also antiproliferative effects, breaking down its responsibility in the GPER transactivation. Nevertheless, it is possible to conclude that the 4,5-dihydropyrrolo[1,2-a]quinoxalines remain a feasible scaffold to develop anticancer agents against GPER-expressing cells.
Journal of Chemistry published new progress about Antiproliferative agents. 51605-97-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H12BrN, Computed Properties of 51605-97-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary