Buckle, Derek R.; Morgan, Neil J.; Ross, Janet W.; Smith, Harry; Spicer, Barbara A. published the artcile< Antiallergic activity of 2-nitroindan-1,3-diones>, Application In Synthesis of 82-73-5, the main research area is nitro indandione antiallergic.
Of 26 2-nitroindan-1,3-diones prepared, 2-nitroindan-1,3-dione (I) [3674-33-7] showed an activity close to that of disodium cromoglycate [15826-37-6] while 5,6-dimethyl-2-nitroindan-1,3-dione (II) [49561-92-4] and 2-nitrobenz[f]indan-1,3-dione (III) [49561-93-5] showed a marked increase in antiallergic activity as measured by the homocytotropic antibody-antigen induced passive cutaneous anaphylaxis reaction in the rat. The prepn of the 1,3-indandione nucleus was achieved by 3 routes, all procedures necessitating the appropriately substituted phthalate precursors which were obtained through a variety of synthetic methods.
Journal of Medicinal Chemistry published new progress about Antihistamines. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application In Synthesis of 82-73-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary