Brandstatter, Marco; Huwyler, Nikolas; Carreira, Erick M. published the artcile< Gold(I)-catalyzed stereoselective cyclization of 1,3-enyne aldehydes by a 1,3-acyloxy migration/Nazarov cyclization/aldol addition cascade>, COA of Formula: C21H22BrP, the main research area is bicyclooctenone preparation diastereoselective enantioselective; enyne aldehyde propargylic acetate preparation cyclization tandem gold catalyst.
Stereoselective synthesis of bicyclo[3.3.0]octenones I (R = Ph, naphthalen-2-yl, i-Pr, etc.) from chiral 1,3-enyne aldehydes bearing propargylic acetates (R,E/Z)-CH3CH(OC(O)CH3)CCC(R)=CH(CH2)2CHO is described. The method is based on a Au(I)-catalyzed domino sequence with concomitant transfer of chirality involving 1,3-acyloxy migration followed by Nazarov cyclization and an unprecedented aldol addition The method furnishes densely functionalized bicyclic structures in high yields, with up to 97% ee and good diastereoselectivity.
Chemical Science published new progress about Aldol addition catalysts, stereoselective. 1530-33-2 belongs to class bromides-buliding-blocks, and the molecular formula is C21H22BrP, COA of Formula: C21H22BrP.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary