Xiao, Guiying; Xie, Chaochao; Guo, Qianling; Zi, Guofu; Hou, Guohua; Huang, Yuping published the artcile< Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives>, Synthetic Route of 401-78-5, the main research area is lactone preparation enantioselective; keto acid hydrogenation nickel catalyst; hydroxy ester preparation enantioselective; ketoester hydrogenation nickel catalyst; hydroxyamide preparation enantioselective; ketoamide hydrogenation nickel catalyst.
A highly efficient asym. hydrogenation of a series of γ-keto acid derivatives, including γ-keto acids RC(O)CH2CH2C(O)OH (R = Me, Ph, cyclopentyl, 3,4-dimethylphenyl, etc.), esters RC(O)CH2CH2C(O)OR1 (R1 = Me, Et, t-Bu), and amides RC(O)CH2CH2C(O)NR2R3 (R2 = H, Bn, iPr; R3 = H, iPr), using a Ni-(R,R)-QuinoxP* complex as the catalyst has been developed to afford chiral γ-hydroxy acid derivatives RCH(OH)CH2CH2C(O)OR1 and RCH(OH)CH2CH2C(O)NR2R3 with excellent enantioselectivities, up to 99.9% ee. This method provides not only an economical one-pot approach for the synthesis of chiral γ-lactones I but also access to (S)-norfluoxetine, an inhibitor of neural serotonin reuptake and an essential intermediate for pharmaceutical synthesis.
Organic Letters published new progress about Amides, hydroxy Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Synthetic Route of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary