Wan, Pui-Ki; Tong, Ka-Chung; Lok, Chun-Nam; Zhang, Chunlei; Chang, Xiao-Yong; Sze, Kong-Hung; Tsai Wong, Alice Sze; Che, Chi-Ming published an article in 2021. The article was titled 《Platinum(II) N-heterocyclic carbene complexes arrest metastatic tumor growth》, and you may find the article in Proceedings of the National Academy of Sciences of the United States of America.Electric Literature of C13H17BrO9 The information in the text is summarized as follows:
Platinum cationic arylbipyridine cyclometalated NHC complexes, substituted with hydroxyalkyl and carbohydrate groups, were prepared as antitumor agents effective against metastatic and cisplatin-resistant cancers. Vimentin is a cytoskeletal intermediate filament protein that plays pivotal roles in tumor initiation, progression, and metastasis, and its overexpression in aggressive cancers predicted poor prognosis. Herein described is a highly effective antitumor and antimetastatic metal complex [Pt(C-N-N)(NHC)][PF6] (1a; HC-N-N = 6-phenyl-2,2′-bipyridine; NHC = 1,3-dibutyl-2-imidazolylidene) that engages vimentin via noncovalent binding interactions with a distinct orthogonal structural scaffold. The complex 1a displays vimentin-binding affinity with a dissociation constant of 1.06μM from surface plasmon resonance measurements and fits into a pocket between the coiled coils of the rod domain of vimentin with multiple hydrophobic interactions. It engages vimentin in cellulo, disrupts vimentin cytoskeleton, reduces vimentin expression in tumors, suppresses xenograft growth and metastasis in different mouse models, and is well tolerated, attributable to biotransformation to less toxic and renal-clearable platinum(II) species. Our studies uncovered the practical therapeutic potential of platinum(II)-NHC complexes as effective targeted chemotherapy for combating metastatic and cisplatin-resistant cancers.(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3Electric Literature of C13H17BrO9) was used in this study.
(2R,3R,4S,5S,6S)-2-Bromo-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate(cas: 21085-72-3) may be used for the synthesis of HMR1098-S-Glucuronide Methyl Ester, a new K-ATP-blocking agent being developed as a drug for prevention of sudden cardiac death.Electric Literature of C13H17BrO9
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary