Sun, Huai-Ri; Zhao, Qingyang; Yang, Hui; Yang, Sen; Gou, Bo-Bo; Chen, Jie; Zhou, Ling published the artcile< Chiral Phosphoric-Acid-Catalyzed Cascade Prins Cyclization>, Electric Literature of 29124-57-0, the main research area is chiral phosphoric acid catalyst cascade Prins cyclization; trans fused pyrano furo tetrahydroquinoline stereoselective preparation; stereoselective cascade Prins cyclization quinone methide aminobenzaldehyde.
Asym. Prins cyclization of in situ generated quinone methides and o-aminobenzaldehyde has been developed with chiral phosphoric acid as an efficient catalyst. This unconventional method provides a facile access to diverse functionalized trans-fused pyrano-/furo-tetrahydroquinoline derivatives in excellent yield and with excellent diastereo- and enantioselectivities (up to 99% yield and 99% ee). Mechanistic studies suggested that the three adjacent tertiary stereocenters were constructed through the sequential formation of C-O, C-C, and C-N bonds.
Organic Letters published new progress about Diastereoselective synthesis. 29124-57-0 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO, Electric Literature of 29124-57-0.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary