Shrimp, Jonathan H.; Jing, Yihang; Gamage, Supuni Thalalla; Nelson, Kathryn M.; Han, Joseph; Bryson, Keri M.; Montgomery, David C.; Thomas, Justin M.; Nance, Kellie D.; Sharma, Sunny; Fox, Stephen D.; Andressen, Thorkell; Sinclair, Wilson R.; Wu, Hong; Allali-Hassani, Abdellah; Senisterra, Guillermo; Vedadi, Masoud; Lafontaine, Denis; Dahlin, Jayme L.; Marmorstein, Ronen; Walters, Michael A.; Meier, Jordan L. published the artcile< Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation>, Computed Properties of 20099-90-5, the main research area is remodelin cryptic assay interference chemotype NAT10 acetylase RNA acetylation.
Remodelin is a putative small mol. inhibitor of the RNA acetyltransferase NAT10 which has shown preclin. efficacy in models of the premature aging disease Hutchinson-Gilford Progeria Syndrome (HGPS). Here we evaluate remodelin’s assay interference characteristics and effects on NAT10-catalyzed RNA cytidine acetylation. We find the remodelin chemotype constitutes a cryptic assay interference compound, which does not react with small mol. thiols but demonstrates protein reactivity in ALARM NMR and proteome-wide affinity profiling assays. Biophys. analyses find no direct evidence for interaction of remodelin with the NAT10 acetyltransferase active site. Cellular studies verify that N4-acetylcytidine (ac4C) is a nonredundant target of NAT10 activity in human cell lines and find that this RNA modification is not affected by remodelin treatment in several orthogonal assays. These studies display the potential for remodelin’s chemotype to interact with multiple protein targets in cells and indicate remodelin should not be applied as a specific chem. inhibitor of NAT10-catalyzed RNA acetylation.
ACS Medicinal Chemistry Letters published new progress about Homo sapiens. 20099-90-5 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO3, Computed Properties of 20099-90-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary