Malysheva, Yulia B.; Combes, Sebastien; Fedorov, Alexey Yu.; Knochel, Paul; Gavryushin, Andrei E. published the artcile< New method of synthesis and biological evaluation of some combretastatin A-4 analogues>, Formula: C12H16BrNO2, the main research area is combretastatin A4 analog stereoselective preparation antitumor.
A series of novel combretastatin A-4 analogs was synthesized in 36-64% yields by Negishi cross-coupling reaction under mild conditions. The prepared compounds exhibit good cytotoxicity against HBL100 epithelial cell lines (IC50 = 0.022-10.31 μM).
Synlett published new progress about Antitumor agents. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Formula: C12H16BrNO2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary