Luening, Ulrich; Fahrenkrug, Frank published the artcile< Synthesis of concave 1,10-phenanthrolines by a combination of Suzuki coupling, ring closing metathesis and hydrogenation>, Safety of 2-Bromo-3-methoxyphenol, the main research area is concave phenanthroline preparation Suzuki ring closing metathesis hydrogenation.
A wide variety of saturated and unsaturated concave 1,10-phenanthrolines have been synthesized in good yields starting from dichloro-1,10-phenanthroline. In the three step synthesis, Suzuki couplings of bis-ortho-substituted boronic acids were used to introduce two different or two identical aryl bridgeheads into the 2- and 9-positions of the 1,10-phenanthroline (yields ≥70%). The resulting diaryl-1,10-phenanthrolines, substituted with alkenyloxy groups of different lengths, underwent ring closing metathesis reactions giving (bi)macrocyclic 1,10-phenanthrolines in yields of 73-96%. The alkene chains of (bi)macrocyclic 1,10-phenanthrolines were saturated using hydrogen and Pd/C giving concave 1,10-phenanthrolines in yields of 75-99%. For example, the ring closing metathesis of a [bis(hexenyloxy)phenyl][(butenyloxy)(hexenyloxy)phenyl]phenanthroline derivative (I) gave an intermediate (II) which was hydrogenated to give a desired concave phenanthroline derivative
European Journal of Organic Chemistry published new progress about Hydrogenation. 135999-16-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H7BrO2, Safety of 2-Bromo-3-methoxyphenol.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary