Li, Han; Sheng, Jie; Wu, Bing-Bing; Li, Yan; Wang, Xi-Sheng published the artcile< Nickel-Catalyzed Cross-Coupling of Ethyl Chlorofluoroacetate with Aryl Bromides>, Synthetic Route of 401-78-5, the main research area is nickel catalyzed cross coupling ethyl chlorofluoroacetate aryl bromide; aryl halides; cross-coupling; ethyl chlorofluoroacetate; monofluoroacetation; nickel.
A combinatorial nickel-catalyzed monofluoroalkylation of aryl bromides with the industrial raw regent Et chlorofluoroacetate has been developed. The two key factors to successful conversion are the combination of nickel with readily available nitrogen and phosphine ligands and the using of a mixture of different solvents. Mechanistic investigations indicated a new zinc regent might generated in situ and be involved in the reaction process.
Chemistry – An Asian Journal published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Synthetic Route of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary