Kim, Yongkyun’s team published research in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2020 | CAS: 2969-81-5

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 4-bromobutyrate

《Highly Regioselective Preparation and Characterization of New 6-O-Substituted Dieckol Derivatives》 was published in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2020. These research results belong to Kim, Yongkyun; Shin, Jooseok; Kang, Su Min; Song, Jinyoung; Shin, Hyeon-Cheol; Keum, Young-Sam; Hwang, Hye Jeong; Park, Kwangyong. Recommanded Product: Ethyl 4-bromobutyrate The article mentions the following:

Dieckol is a brown algae-derived polyphenol that has broad bioactivity and low toxicity. Therefore, it is a promising lead compound for the development of therapeutic agents to treat various pathol. conditions, including viral infections, allergies, diabetes, skin ageing, cancers, and neurodegenerative conditions. To exploit the pharmacol. potential of dieckol, its stability, solubility, pharmacokinetics, and drug delivery must be improved. This can be achieved by the controlled modification of the hydroxyl groups, but the presence of eleven nearly equivalent hydroxyl groups makes the task highly challenging. In this study, the regioselectivities in five substitution reactions of the hydroxyl groups of dieckol under various SN2 reaction conditions were investigated. After reaction optimization, five substituents (Me, benzyl, methoxymethyl, 3-hydroxypropyl, and 3-(ethoxycarbonyl)propyl) could be introduced at the 6-Oposition of dieckol with surprisingly high regioselectivity, as confirmed by 2D-NMR spectroscopic analyses. The prepared dieckol derivatives showed antioxidant and anticancer activities analogous to those of unmodified dieckol, indicating that the mono-O-substitutions did not affect the biochem. and biol. characteristics of dieckol. Therefore, the proposed methodol. for the mono-O-substitution of a specific oxygen of dieckol is a powerful tool to add various pharmaceutical attributes to dieckol, thus contributing to the development of various dieckol-based drug candidates. In addition to this study using Ethyl 4-bromobutyrate, there are many other studies that have used Ethyl 4-bromobutyrate(cas: 2969-81-5Recommanded Product: Ethyl 4-bromobutyrate) was used in this study.

Ethyl 4-bromobutyrate(cas: 2969-81-5) belongs to bromides. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents.Recommanded Product: Ethyl 4-bromobutyrate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary