Hong, Liang; Liu, Chunxia; Sun, Wangsheng; Wang, Lei; Wong, Kwokyin; Wang, Rui published the artcile< Organocatalytic Enantioselective Friedel-Crafts Alkylation of 4,7-Dihydroindoles with α,β-Unsaturated Aldehydes: An Easy Access to 2-Substituted Indoles>, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde, the main research area is dihydroindole unsaturated aldehyde chiral diarylprolinol trimethylsilyl ether; enantioselective Friedel Crafts alkylation benzoquinone oxidation; substituted dihydroindole indole stereoselective preparation; Friedel Crafts alkylation enantioselective catalyst chiral diarylprolinol trimethylsilyl ether.
An enantioselective Friedel-Crafts alkylation of 4,7-dihydroindoles and α,β-unsaturated aldehydes has been developed. The process is promoted by diphenylprolinol ether to afford 2-substituted 4,7-dihydroindoles, e.g., I, in high yields and enantioselectivities. After a subsequent oxidation of the products, the optically active 2-substituted indoles could be obtained smoothly in high yields without any loss of enantioselectivity.
Organic Letters published new progress about Friedel-Crafts reaction (enantioselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Recommanded Product: 3-(4-Bromophenyl)acrylaldehyde.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary