Ge, Shaozhong; Arlow, Sophie I.; Mormino, Michael G.; Hartwig, John F. published the artcile< Pd-Catalyzed α-Arylation of Trimethylsilyl Enolates of α,α-Difluoroacetamides>, Product Details of C12H16BrNO2, the main research area is difluorotrimethylsilylacetamide aryl heteroaryl bromide arylation palladium catalyst; aryl difluoroketone difluoroacetaldehyde difluoroacetate difluoroethanol difluoroethylamine preparation; difluoroethanol ethylamine preparation.
We report the arylation and heteroarylation of α,α-difluoro-α-(trimethylsilyl)acetamides with aryl and heteroaryl bromides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)2Cy as ligand. A broad range of electronically varied aryl and heteroaryl bromides underwent this transformation to afford α-aryl-α,α-difluoroacetamides in high yields. Due to the electrophilicity of the fluorinated amide, this palladium-catalyzed cross-coupling reaction provides a versatile platform to generate a range of α,α-difluoro carbonyl compounds, such as α-aryl-α,α-difluoroketones, -acetaldehydes, -acetates, and acetic acids, and difluoroalkyl derivatives, such as 2-aryl-2,2-difluoroethanols and -ethylamines, under mild conditions.
Journal of the American Chemical Society published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (difluoro trimethylsilyl). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Product Details of C12H16BrNO2.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary