Feng, Xin; Cui, Hai-Lei; Xu, Shi; Wu, Li; Chen, Ying-Chun published the artcile< Organocatalytic Direct Vinylogous Michael Addition of α,β-Unsaturated γ-Butyrolactam to α,β-Unsaturated Aldehydes and an Illustration to Scaffold Diversity Synthesis>, Formula: C9H7BrO, the main research area is alkyl butyrolactam stereoselective preparation; unsaturated butyrolactam aldehyde diastereoselective enantioselective regioselective chemoselective Michael addition; alkaloid stereoselective preparation; butyrolactam reductive amination intramol aza Michael addition; diastereoselective reductive radical conjugate addition cyclization.
The first organocatalytic regio- and chemoselective direct vinylogous Michael addition of N-Boc α,β-unsaturated γ-butyrolactam to α,β-unsaturated aldehydes is reported. The desired adducts, e.g. I, with multiple orthogonal sets of functionalities were obtained in excellent enantioselectivity (up to 98% ee) with low to outstanding diastereoselectivity (d.r. up to > 20:1). Moreover, it has been demonstrated that the products were quite valuable for scaffold diversity synthesis. A number of enantioenriched natural-product-like or drug-like mols. with fused bi-, tri-, and polycyclic structures, e.g. II, have been efficiently constructed, which might have potentials in the later explorations for the biol. related studies.
Chemistry – A European Journal published new progress about Alkaloids Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Formula: C9H7BrO.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary