Du, Shaoqing; Hu, Xueping; Shao, Xusheng; Qian, Xuhong published the artcile< Novel trifluoromethyl sydnone derivatives: Design, synthesis and fungicidal activity>, Recommanded Product: 4-Bromobenzylamine, the main research area is trifuoromethyl sydnone derivative preparation antifungal; Antifungal; Mesoionic; Sydnone; Trifluoromethyl.
In this study, a series of noval sydnone mesoionic derivatives I (R1 = H, Ph, 3-trifluoromethylphenyl, 3,5-dichlorophenyl; R2 = 3-trifluoromethylphenyl, tetrahydrofuran-2-yl, cylcopropyl, etc.) by active substructure splicing were designed and synthesized. All compounds were characterized using 1H and 13C NMR spectroscopy. Among them, trifluoromethyl compound I (R1 = R2 = 3-trifluoromethylphenyl) showed good bioactivity against Pseudoperonospora cubensis (EC50 = 49 mg L-1) in vivo, the activity was similar to that of the control Kresoxim-Me (EC50 = 44 mg L-1). However, the target of these compounds should not only be tyrosinase, and the mode of action needs to be further studied. In addition, the structure-activity relationship indicated that the trifluoromethyl group was more beneficial for antifungal activity. This is the first report that fluorine-containing N(3)-benzyl sydnone compounds have good fungicidal activity. These results will provide a basis for the development of sydnone mesoionic as new lead fungicidal agents.
Bioorganic & Medicinal Chemistry Letters published new progress about Agrochemical fungicides. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Recommanded Product: 4-Bromobenzylamine.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary