Domaradzki, Maciej E.; Liu, Xiaochen; Ong, Jiye; Yu, Gyeongah; Zhang, Gan; Simantov, Ariel; Perl, Eliyahu; Chen, Yu published the artcile< Triflic acid mediated sequential cyclization of ortho-alkynylarylesters with ammonium acetate>, Quality Control of 17100-65-1, the main research area is isoquinolinone isochromenone preparation; alkynylarylester intramol cyclization triflic acid ammonium acetate.
A triflic acid (TfOH) mediated sequential cyclization of ortho-alkynylarylesters and ammonium acetate (NH4OAc) was reported. The reaction took place via a Bronsted acid-mediated intramol. cyclization of ortho-alkynylarylesters followed by an ammonium acetate participated substitution reaction, forming isoquinolin-1-ones as the major products. Different from most of the known synthetic methods of isoquinolin-1-ones, no metal catalyst was required in the reported reaction. The regioisomers – isoindolin-1-ones were obtained together with isoquinolin-1-ones in a few cases. The intermediate compounds – isochromen-1-ones and isobenzofuran-1-ones were also isolated. The interconversion experiments showed that the regioisomers formed during the Bronsted acid induced intramol. cyclization of ortho-alkynylarylesters. A natural product – ruprechstyril was prepared in a moderate yield employing the new method.
Tetrahedron published new progress about Benzopyrans Role: SPN (Synthetic Preparation), PREP (Preparation) (isochromenones). 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Quality Control of 17100-65-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary