《Convergent charge interval spacing of zwitterionic 4-vinylpyridine carboxybetaine structures for superior blood-inert regulation in amphiphilic phases》 was written by Chiu, Chieh-Yang; Chang, Yung; Liu, Tzu-Hao; Chou, Ying-Nien; Yen, Ta-Jen. Quality Control of 4-Bromobutanoic acidThis research focused onzwitterionic vinylpyridine carboxybetaine blood regulation amphiphilic phase. The article conveys some information:
Antifouling materials are indispensable in the biomedical field, but their high hydrophilicity and surface free energy provoke contamination on surfaces under atm. conditions, thus limiting their applicability in medical devices. This study proposes a new zwitterionic structure, 4-vinylpyridine carboxybetaine (4VPCB), that results in lower surface free energy and increases biol. inertness. In the design of 4VPCB, one to three carbon atoms are inserted between the pos. charge and neg. charge (carbon space length, CSL) of the pyridyl-containing side chain to adjust hydration with water mols. The pyridine in the 4VPCB structure provides the hydrophobicity of the zwitterionic functional group, and thus it can have a lower free energy in the gas phase but maintain higher hydrophilicity in the liquid phase environment. Surface plasmon resonance and confocal microscopy were used to analyze the antiprotein adsorption and anti-blood cell adhesion properties of the P4VPCB brush surface. The results showed that the CSL in the P4VPCB structure affected the biol. inertness of the surface. The protein adsorption on the surface of P4VPCB2 (CSL= 2) is lower than that on the surfaces of P4VPCB1 (CSL = 1) and P4VPCB3 (CSL = 3), and the optimal resistance to protein adsorption can be reduced to 7.5 ng cm-2. The surface of P4VPCB2 can also exhibit excellent blood-inert function in the adhesion test with various human blood cells, offering a potential possibility for the future design of a new generation of blood-inert medical materials. In the experiment, the researchers used many compounds, for example, 4-Bromobutanoic acid(cas: 2623-87-2Quality Control of 4-Bromobutanoic acid)
4-Bromobutanoic acid(cas: 2623-87-2) belongs to carboxylic acids. The chief chemical characteristic of the carboxylic acids is their acidity. They are generally more acidic than other organic compounds containing hydroxyl groups but are generally weaker than the familiar mineral acids (e.g., hydrochloric acid, HCl, sulfuric acid, H2SO4, etc.).Quality Control of 4-Bromobutanoic acid
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary