Barik, Soumen; Das, Rohan Chandra; Balanna, Kuruva; Biju, Akkattu T. published the artcile< Kinetic Resolution Approach to the Synthesis of C-N Axially Chiral N-Aryl Aminomaleimides via NHC-Catalyzed [3 + 3] Annulation>, Category: bromides-buliding-blocks, the main research area is phenyl aminopyrrolidione bromopropenal arene heterocyclic carbene cycloaddition kinetic resolution; aryl pyrrolopyridine trione preparation.
Chiral NHC-catalyzed kinetic resolution of N-aryl aminomaleimides allowing the synthesis of C-N axially chiral N-aryl aminomaleimides via remote chirality control was presented. The catalytically generated α,β-unsaturated acylazoliums from 2-bromoenals underwent selective [3 + 3] annulation with one of the enantiomers of maleimide to furnish fused-dihydropyridinone (bearing axial/central chirality, up to 6:1 dr, >99:1 er) leaving the enantioenriched opposite enantiomer (up to >99:1 er). Studies on C-N bond rotation barrier and dependence on temperature were also provided.
Organic Letters published new progress about [3+3] Cycloaddition reaction (stereoselective). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary