Zheng, Yan-Long; Newman, Stephen G. published the artcile< Nickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles>, Electric Literature of 17100-65-1, the main research area is nickel catalyst Heck Suzuki Miyaura coupling methyl ester electrophile; cross-coupling; cyclizations; esters; homogeneous catalysis; nickel.
While esters are frequently used as traditional electrophiles in substitution chem., their application in cross-coupling chem. is still in its infancy. Me esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)-O bond under relatively mild reaction conditions at either 80 or 100°. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C:C bond, carbonyl-retentive products were formed by domino Heck/Suzuki-Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles were used.
Angewandte Chemie, International Edition published new progress about Cross-coupling reaction. 17100-65-1 belongs to class bromides-buliding-blocks, and the molecular formula is C9H9BrO3, Electric Literature of 17100-65-1.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary