Zhang, Zhipeng; Yu, Yang; Huang, Fei; Yi, Xiangyan; Xu, Yao; He, Yide; Baell, Jonathan B.; Huang, He published the artcile< Catalytic O-H bond insertion reactions using surface modified sewage sludge as a catalyst>, Product Details of C7H4BrF3O, the main research area is diazoester phenol sewage sludge catalyst insertion reaction green chem; phenoxy acetate preparation antitumor antiinflammatory activity cytotoxicity.
The more economical and greener surface modified sewage sludge-derived carbonaceous materials (SW) treated by perchloric acid as a new catalyst for carbene insertion of α-aryl α-diazoacetates into O-H bonds of phenols with good yields and high functional group tolerance was reported. The scope of natural phenols with compelling biol. activity, and successfully afforded the O-H insertion and meta C-H functionalization products was explored. Their structures was confirmed by single-crystal X-ray crystallog. Furthermore, the bioactivities (anti-tumor and anti-inflammatory) of the majority of O-H insertion products were better than those of the natural phenols themselves. The IC50 values indicated that the remarkable compounds I [ R1 = phenyl; R2 = ethyl] (IC50 = 16.80μM) and I [R1 = phenyl; R2 = prop-2-en-1-yl] (IC50 = 16.48μM) had better inhibition for tumor cell A-549 than pos. control DDP (IC50 = 20.62μM). It should be noted that these transformations was provided a new strategy to derive natural products and discover new drugs.
Green Chemistry published new progress about Acetates Role: PAC (Pharmacological Activity), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 81107-97-3 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3O, Product Details of C7H4BrF3O.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary