Zhang, Song-Lin; Yu, Ze-Long published the artcile< Divergent synthesis of indoles, oxindoles, isocoumarins and isoquinolinones by general Pd-catalyzed retro-aldol/α-arylation>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is indole oxindole isocoumarin isoquinolinone preparation; aryl halide hydroxy carbonyl retro aldol arylation palladium catalyst.
Divergent synthesis of indoles I (R = H, 6-CH3, 5-F, etc.; R1 = CH3, C6H5), oxindoles II, isocoumarins e.g., III and isoquinolinones IV (R2 = CH3, C6H5) is described in this report by using a general Pd-catalyzed tandem reaction of β-hydroxy carbonyl compounds R3C(O)CH2C(R4)(OH)CH3 (R3 = CH3, C6H5, OCH3CH2; R4 = CH3, C6H5) with aryl halides bearing an ortho-nitro, -ester or -cyano substituent e.g., Me 2-chloropyridine-3-carboxylate. A key retro-aldol/α-arylation reaction is involved that merges classic Pd cross-coupling chem. with novel Pd-promoted retro-aldol C-C activation to produce α-arylated ketones or esters. Subsequent intramol. condensation of the carbonyl with the ortho-synthon gives target heterocycles I, II, e.g., III and IV. The use of common, com. available and cheap substrates and catalyst system adds addnl. synthetic advantages to the conceptual significance.
Organic & Biomolecular Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary