Yadav, Suman; Reshi, Noor U. Din; Pal, Saikat; Bera, Jitendra K. published the artcile< Aerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex>, Safety of 4-Bromobenzylamine, the main research area is primary amine ruthenium catalyst aerobic oxidation; amide preparation.
Catalytic aerobic oxidation of primary amines to the amides, using the precatalyst [Ru(COD)(L1)Br2] bearing an annulated π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand L1, was disclosed. This catalytic protocol was distinguished by its high activity and selectivity, wide substrate scope and modest reaction conditions. A variety of primary amines, RCH2NH2 (R = aliphatic, aromatic and heteroaromatic), were converted to the corresponding amides using ambient air as an oxidant in the presence of a sub-stoichiometric amount of KOtBu in tBuOH. A set of control experiments, Hammett relationships, kinetic studies and DFT calculations were undertaken to divulge mechanistic details of the amine oxidation using [Ru(COD)(L1)Br2]. The catalytic reaction involveed abstraction of two amine protons and two benzylic hydrogen atoms of the metal-bound primary amine by the oxo and hydroxo ligands, resp. A β-hydride transfer step for the benzylic C-H bond cleavage was not supported by Hammett studies. The nitrile generated by the catalytic oxidation undergoes hydration to afford the amide as the final product.
Catalysis Science & Technology published new progress about Activation enthalpy. 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Safety of 4-Bromobenzylamine.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary