Xu, Chao; Fyfe, James W. B.; Seath, Ciaran P.; Bennett, Steven H.; Watson, Allan J. B. published the artcile< A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system>, Reference of 188813-04-9, the main research area is biaryl chemoselective microwave irradiation; haloaryl aldehyde BPin allylation Suzuki Miyaura.
A chemoselective tandem reaction of a multi-reactive, two electrophile + two nucleophile, system was reported. An allylation/cross-coupling process of aryl/allyl BPins e.g., 2-propenylboronic acid pinacol ester, haloaryl aldehydes such as 4-bromobenzaldehyde, 6-bromonicotinaldehyde, (E)-5-iodopent-4-enal, etc. can be controlled using a temperature gradient to overcome natural reactivity profiles and allow two sequential chemoselective C-C bond formations without intervention to afforded biaryls e.g., I scaffold of products. This process offers efficient access to an array of functionalized products including pharmaceutical and natural product scaffolds.
Chemical Communications (Cambridge, United Kingdom) published new progress about Allylation (chemoselective). 188813-04-9 belongs to class bromides-buliding-blocks, and the molecular formula is C8H7BrO, Reference of 188813-04-9.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary