Wu, Ting-Feng; Zhang, Yue-Jiao; Fu, Yue; Liu, Fang-Jie; Tang, Jian-Tao; Liu, Peng; Toste, F. Dean; Ye, Baihua published the artcile< Zirconium-redox-shuttled cross-electrophile coupling of aromatic and heteroaromatic halides>, Synthetic Route of 401-78-5, the main research area is biaryl preparation; aryl halide cross coupling zirconium redox catalyst.
Herein, a homogeneous XEC method, which relied on a zirconaaziridine complex as a shuttle for dual palladium-catalyzed processes was reported. The zirconaaziridine-mediated palladium (ZAPd)-catalyzed reaction showed excellent compatibility with various functional groups and diverse heteroaromatic scaffolds. In accord with d. functional theory (DFT) calculations, a redox transmetallation between the oxidative addition product and the zirconaaziridine was proposed as the crucial elementary step. Thus, cross-coupling selectivity using a single transition metal catalyst was controlled by the relative rate of oxidative addition of Pd(0) into the aromatic halide. Overall, the concept of a combined reducing and transmetallating agent offered opportunities for the development of transition metal reductive coupling catalysis.
Chem published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Synthetic Route of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary