Vechorkin, Oleg; Godinat, Aurelien; Scopelliti, Rosario; Hu, Xile published the artcile< Cross-Coupling of Nonactivated Alkyl Halides with Alkynyl Grignard Reagents: A Nickel Pincer Complex as the Catalyst>, Application In Synthesis of 639520-70-0, the main research area is alkyl halide alkynyl Grignard cross coupling nickel catalysis.
Alkynes containing nonactivated alkyl groups, especially those with β-hydrogen atoms, are difficult to synthesize. In this paper, we have disclosed the first general nickel-catalyzed cross-coupling of nonactivated alkyl halides with alkynyl Grignard reagents. The wide scope and high functional group tolerance makes the method attractive for the streamlined preparation of alkynes containing nonactivated alkyl groups. At this moment, only primary alkyl halides can be coupled. Methods to couple secondary alkyl halides are currently being developed in our laboratory
Angewandte Chemie, International Edition published new progress about Cross-coupling reaction. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Application In Synthesis of 639520-70-0.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary