Tanaka, Yuta; Kurasawa, Osamu; Yokota, Akihiro; Klein, Michael G.; Saito, Bunnai; Matsumoto, Shigemitsu; Okaniwa, Masanori; Ambrus-Aikelin, Geza; Uchiyama, Noriko; Morishita, Daisuke; Kimura, Hiromichi; Imamura, Shinichi published the artcile< New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase>, HPLC of Formula: 337536-14-8, the main research area is allosteric deoxyhypusine synthase inhibitor preparation pharmacokinetics SAR.
In this work, a new chem. series possessing fused ring scaffolds designed from high-throughput screening hit compounds was synthesized, discovering a 5,6-dihydrothieno[2,3-c]pyridine derivative I [R = (R)-i-Bu] with potent inhibitory activity. Furthermore, the X-ray crystallog. anal. of the DHPS complex with I [R = (R)-i-Bu] demonstrated a distinct allosteric binding mode compared to a previously reported inhibitor. These findings could be significantly useful in the functional anal. of conformational changes in DHPS as well as the structure-based design of allosteric inhibitors.
ACS Medicinal Chemistry Letters published new progress about Allosteric modulators. 337536-14-8 belongs to class bromides-buliding-blocks, and the molecular formula is C9H8Br2O2, HPLC of Formula: 337536-14-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary