Peng, Lingteng; Hu, Zhifang; Zhao, Yanting; Peng, Lifen; Xu, Zhi; Yin, Shuang-Feng; Tang, Zilong; Qiu, Renhua; Kambe, Nobuaki published the artcile< One-pot synthesis of phosphorylnaphth[2,1-d]oxazoles and products as P,N-ligands in C-N and C-C formation>, Application of C7H8BrN, the main research area is carbon nitrogen bond formation palladium catalyst nickel phosphinylnaphthoxazole; crystal structure mol phosphinylnaphthoxazole methoxy phenyl preparation; phosphorylnaphthoxazole preparation coupling catalyst nitrogen carbon bond formation.
Phosphinylnaphtho[2,1-d]oxazoles were synthesized successfully through one-pot phosphonation of naphthoquinone with diaryl(alkyl)phosphine oxides and Cu-catalyzed oxidative condensation with imines, followed by methylation and reduction Upon applying 4-phosphinylnaphtho[2,1-d]oxazole as a P,N-chelating ligand, Pd-catalyzed C-N formation of amines or nitrobenzene as well as Ni-catalyzed C-C formation and the synthesis of quinoline proceeded successfully. The reaction was facilely scaled up to give a N-benzylaniline in a gram scale synthesis. This research provided a facile and convenient protocol to synthesize phosphinylnaphtho[2,1-d]oxazoles, which could be applied as an efficient P,N-ligand in transition-metal-catalyzed C-N and C-C formation to produce the desired products in high yields with wide functional group tolerance under small catalyst loading, solvent-free conditions in many reactions.
Organic & Biomolecular Chemistry published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 3959-07-7 belongs to class bromides-buliding-blocks, and the molecular formula is C7H8BrN, Application of C7H8BrN.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary