Patel, Harun; Chaudhari, Kavita; Jain, Pritam; Surana, Sanjay published the artcile< Synthesis and in vitro antitubercular activity of pyridine analouges against the resistant Mycobacterium tuberculosis>, Application In Synthesis of 82-73-5, the main research area is pyridinyl hydrazide preparation antitubercular activity SAR; Schiff base pyridinyl preparation antitubercular activity SAR; Cytotoxicity; MDR-MTB; Mycobacterium tuberculosis; Synthesis.
Synthesis and the biol. activity of isoniazid and pyridine derivatives were successfully carried out with elaborated characterization by spectral data. Amongst the synthesized compounds; I and II displayed encouraging antimycobacterial activity with IC50 of 3.2μM and 1.5μM against the H37Rv strain. The MIC of test compounds I and II were also assessed against the 5 drug resistant isolates (FQ-R1, INH-R1, INH-R2, RIF-R1 and RIF-R2) of MTB strains under aerobic conditions and compound I [MIC = 3.2μM for FQ-R1; MIC = 140μM for INH-R1; MIC = 160μM for INH-R2; MIC = 2.4μM towards RIF-R1; MIC = 4.2μM for RIF-R2] and II [MIC = 3.3μM for FQ-R1; MIC = 170μM for INH-R1; MIC = 190μM for INH-R2; MIC = 1.8μM for RIF-R1; MIC = 8.4μM for RIF-R2] have shown significant activity at non-cytotoxic concentration in comparison to the standard drug.
Bioorganic Chemistry published new progress about Drug toxicity. 82-73-5 belongs to class bromides-buliding-blocks, and the molecular formula is C8H3BrO3, Application In Synthesis of 82-73-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary