Nagaki, Aiichiro; Jiang, Yiyuan; Yamashita, Hiroki; Takabayashi, Naoshi; Takahashi, Yusuke; Yoshida, Jun-ichi published the artcile< Monolithiation of 5,5'-Dibromo-2,2'-bithiophene Using Flow Microreactors: Mechanistic Implications and Synthetic Applications>, Electric Literature of 3480-11-3, the main research area is monolithiation dibromo bithiophene flow microreactor methyllithium.
The lithiation of 5,5′-dibromo-2,2′-bithiophene with one equivalent of an alkyllithium such as n-BuLi or s-BuLi was studied by varying the residence time in flow microreactors. With a short residence time, the product 2,2′-bithiophene derived from dilithiation was obtained preferentially and a significant amount of the starting material 5,5′-dibromo-2,2′-bithiophene remained unchanged. An increase in the residence time caused a higher yield of the product 5-bromo-2,2′-bithiophene derived from monolithiation with expense in the yields of 2,2′-bithiophene and 5,5′-dibromo-2,2′-bithiophene. The lithiation using MeLi gave the product 5-bromo-2,2′-bithiophene preferentially even with a very short residence time.
Chemical Engineering & Technology published new progress about Aryl bromides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3480-11-3 belongs to class bromides-buliding-blocks, and the molecular formula is C8H5BrS2, Electric Literature of 3480-11-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary