Morack, Tobias; Mueck-Lichtenfeld, Christian; Gilmour, Ryan published the artcile< Bioinspired Radical Stetter Reaction: Radical Umpolung Enabled by Ion-Pair Photocatalysis>, Electric Literature of 3893-18-3, the main research area is bioinspired Stetter keto acid aldehyde radical umpolung photocatalysis; Stetter reaction; electrostatic interactions; ion pairs; radicals; umpolung.
A bioinspired, intermol. radical Stetter reaction of α-keto acids and aldehydes is disclosed that is contingent on a formal “”radical umpolung”” concept. Enabled by secondary amine activation, electrostatic recognition ensures that the α-ketocarboxylic acids, which function as latent acyl radicals, are proximal to the in situ generated iminium salts. This photoactive contact ion pair is an electron donor-acceptor (EDA) complex, and undergoes facile single electron transfer (SET) and rapid decarboxylation prior to radical-radical recombination. Importantly, decarbonylation is mitigated by this strategy. The initial computational validation on which the process is predicated matches closely with experiment Synergistic organo- and photocatalysis activation principles finally expands the mechanistic and synthetic scope of the classic Stetter reaction to include α,β-unsaturated aldehydes as acceptors.
Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Electric Literature of 3893-18-3.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary