Long, Rong; Huang, Jun; Shao, Wenbin; Liu, Song; Lan, Yu; Gong, Jianxian; Yang, Zhen published the artcile< Asymmetric total synthesis of (-)-lingzhiol via a Rh-catalysed [3+2] cycloaddition>, Application In Synthesis of 16426-64-5, the main research area is lingzhiol asym total synthesis rhodium catalyzed cycloaddition.
The development of efficient reactions for the one-pot construction of bicyclic ring systems bearing two quaternary carbon centers at their bridgehead positions represents a significant challenge to synthetic chem. The development of new methods capable of overcoming this challenge is highly desirable, because this motif can be found in a wide range of natural products with significant biol. activities. Herein, we report an efficient [3+2] cycloaddition reaction between an enal and an alleno rhodium species, which was generated in situ from the corresponding enynol via a retro metal-propargylation reaction, to give [3.3.0] and [3.4.0] bicyclic systems bearing two quaternary atoms at their bridgehead positions. The developed chem. has been successfully applied to the asym. total synthesis of natural product (-)-lingzhiol (I) for the first time in 17 steps.
Nature Communications published new progress about [3+2] Cycloaddition reaction, stereoselective. 16426-64-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrNO4, Application In Synthesis of 16426-64-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary