Liu, Lin; Guo, Kai-Xin; Tian, Yu; Yang, Chang-Jiang; Gu, Qiang-Shuai; Li, Zhong-Liang; Ye, Liu; Liu, Xin-Yuan published the artcile< Copper-Catalyzed Intermolecular Enantioselective Radical Oxidative C(sp3)-H/C(sp)-H Cross-Coupling with Rationally Designed Oxazoline-Derived N,N,P(O)-Ligands>, Quality Control of 2725-82-8, the main research area is cycloalkene alkyne copper catalyst regioselective enantioselective oxidative cross coupling; cycloalkenyl alkyne preparation; alkyne aryl alkene copper catalyst enantioselective oxidative cross coupling; aryl alkyne preparation regioselective; alkynylation; anionic N,N,P(O)-ligands; copper catalysis; oxidative cross-coupling; radical asymmetric chemistry.
Here, a copper-catalyzed asym. C(sp3)-C(sp) cross-coupling of (hetero)benzylic and (cyclic)allylic C-H bonds with terminal alkynes that occurs with high to excellent enantioselectivity was reported. Critical to the success is the rational design of chiral oxazoline-derived N,N,P(O)-ligands that not only tolerate the strong oxidative conditions which were requisite for intermol. hydrogen atom abstraction (HAA) processes but also induce the challenging enantiocontrol. Direct access to a range of synthetically useful chiral benzylic alkynes and 1,4-enynes, high site-selectivity among similar C(sp3)-H bonds, and facile synthesis of enantioenriched medicinally relevant compounds make this approach very attractive.
Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Quality Control of 2725-82-8.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary