Li, Xuejing; Deng, Xingwang; Coyne, Anthony G.; Srinivasan, Rajavel published the artcile< meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C-H Borylation>, Application of C8H9Br, the main research area is meta nitroarene regioselective preparation; arene borylation nitration tandem iridium catalyst copper; C−H borylation; copper catalysis; nitration; nitro(hetero)arenes; one-pot reactions.
The meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C-H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes RNO2 [R = 4,5-di-ClC6H3, 3,4-di-BrC6H3, 5-Cl-3-pyridyl, etc.] in a one-pot fashion was reported. The reaction tolerated a wide array of ortho/para-directing groups, such as -F, -Cl, -Br, -CH3, -Et, -iPr -OCH3 and -OCF3. It also provided regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives The application of this method was demonstrated in the late-stage modification of complex mols. and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, showed that the nitro product obtained by this strategy could also be directly converted to the aniline or hindered amine through Baran’s amination protocol.
Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 2725-82-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H9Br, Application of C8H9Br.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary