Li, Bryan; Samp, Lacey; Sagal, John; Hayward, Cheryl M.; Yang, Christine; Zhang, Zhijun published the artcile< Synthesis of Quinazolin-4(3H)-ones via Amidine N-Arylation>, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate, the main research area is trifluoromethyliodonicotinic acid amidine palladium catalyst arylation; pyridopyrimidinone preparation; amindine halobenzoate palladium catalyst arylation; quinazolinone preparation.
Pyrido[4,3-d]pyrimidin-4(3H)-one was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid with amidine I catalyzed by Pd2(dba)3 and Xantphos, followed by cyclization effected with HBTU and subsequent demethylation using PhBCl2. The amidine arylation method was found applicable for the syntheses of quinazolin-4(3H)-ones. Thus, reaction of 2-bromo or 2-iodo benzoate esters with amidines afforded substituted quinazolin-4(3H)-ones, e.g. II, in 44-89% yields.
Journal of Organic Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary