Kong, Xiang-Fei; Guo, Xiu-Yun; Gu, Zi-Yu; Wei, Lin-Su; Liu, Lu-Lu; Mo, Dong-Liang; Pan, Cheng-Xue; Su, Gui-Fa published the artcile< Silver(I)-catalyzed selective hydroalkoxylation of C2-alkynyl quinazolinones to synthesize quinazolinone-fused eight-membered N,O-heterocycles>, Category: bromides-buliding-blocks, the main research area is quinazoline fuse oxygen nitrogen heterocycle preparation antiiflammation.
A silver-catalyzed hydroalkoxylation of C2-alkynyl quinazolinones to prepare a series of novel quinazolinone-fused eight-membered N,O-heterocycles I [X = O, N; R1 = H, 12-Me, 12-MeO, etc; R2 = H, 2-MeO, 2-Br, etc; R3=R4 = H, Me, etc; R5 = H, n-pentyl, Ph, etc] in good-to-excellent yields through a selective 8-endo-dig cyclization. Mechanistic studies revealed that the silver catalyst might aid bidentate coordination of an imine group and alkyne to facilitate 8-endo-dig cyclization to afford eight-membered N,O-heterocycles I. Also, the proposed bimetal silver intermediates might promote hydroalkoxylation rapidly for quinazolinones bearing terminal alkynes at the C2-position. Biol. evaluations revealed that most of the designed quinazolinone-fused eight-membered N,O-heterocycles I inhibited nitric-oxide generation significantly in lipopolysaccharide-stimulated RAW264.7 cells and displayed their bioactivity as potentially good anti-inflammatory agents.
Organic Chemistry Frontiers published new progress about Alkoxylation catalysts, reductive (regioselective). 20776-50-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H6BrNO2, Category: bromides-buliding-blocks.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary