Kim, Yeseul; Kim, Sanghun; Cho, Kiu-Hyung; Lee, Jin-Hyung; Lee, Jintae published the artcile< Antibiofilm Activities of Cinnamaldehyde Analogs against Uropathogenic Escherichia coli and Staphylococcus aureus>, Product Details of C9H7BrO, the main research area is Escherichia coli Staphylococcus aureus cinnamaldehyde uropathogenic antibiofilm activity; Staphylococcus aureus; antibiofilm; cinnamaldehyde; uropathogenic Escherichia coli.
Bacterial biofilm formation is a major cause of drug resistance and bacterial persistence; thus, controlling pathogenic biofilms is an important component of strategies targeting infectious bacterial diseases. Cinnamaldehyde (CNMA) has broad-spectrum antimicrobial and antibiofilm activities. In this study, we investigated the antibiofilm effects of ten CNMA derivatives and trans-CNMA against Gram-neg. uropathogenic Escherichia coli (UPEC) and Gram-pos. Staphylococcus aureus. Among the CNMA analogs tested, 4-nitrocinnamaldehyde (4-nitroCNMA) showed antibacterial and antibiofilm activities against UPEC and S. aureus with min. inhibitory concentrations (MICs) for cell growth of 100 mug/mL, which were much more active than those of trans-CNMA. 4-NitroCNMA inhibited UPEC swimming motility, and both trans-CNMA and 4-nitroCNMA reduced extracellular polymeric substance production by UPEC. Furthermore, 4-nitroCNMA inhibited the formation of mixed UPEC/S. aureus biofilms. Collectively, our observations indicate that trans-CNMA and 4-nitroCNMA potently inhibit biofilm formation by UPEC and S. aureus. We suggest efforts be made to determine the therapeutic scope of CNMA analogs, as our results suggest CNMA derivatives have potential therapeutic use for biofilm-associated diseases.
International Journal of Molecular Sciences published new progress about Antibiofilm agents. 3893-18-3 belongs to class bromides-buliding-blocks, and the molecular formula is C9H7BrO, Product Details of C9H7BrO.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary