Huang, Shuaishuai; Nie, Yixue; Yang, Jingjing; Zheng, Zhanjiang; Cao, Jian; Xu, Zheng; Xu, Liwen published the artcile< Copper-catalyzed arylated etherification of 2,2-difluoroethanol and its mechanistic study>, Electric Literature of 401-78-5, the main research area is haloarene difluoroethanol copper catalyst Ullmann type arylated etherification; difluoroethoxy arene preparation.
A mild and efficient method for the preparation of difluoroethyl aryl ethers was developed by the copper-catalyzed Ullmann-type arylated etherification reaction of aryl bromides or iodides with 2,2-difluoroethanol. This reaction proceeded smoothly in the presence of CuI and 8-hydroxyquinoline/t-BuOK and has a broad substrate scope. ESI-MS anal. supported the existence of LCu(III)Ar(OR) species during this catalytic reaction. Further d. functional theory (DFT) calculations suggested a proposed mechanism of arylated etherification reaction involving oxidative addition, followed by nucleophile substitution and reductive elimination would be rational.
Youji Huaxue published new progress about Alkyl aryl ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 401-78-5 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4BrF3, Electric Literature of 401-78-5.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary